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For each of the available variants with MAF ≥ 0.01 and imputation quality oevar ≥0.3, a Manhattan plot provides its −log) in the combined discovery sample.
Two common variants reached genome-wide significance (Table 2).
However, there was no significant evidence for heterogeneity between the Mainland and the Caribbean groups (p-value for heterogeneity = 0.21).
In the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the overall age-adjusted prevalence of hypertension was 25.5%, but prevalence ranged from as low as 17% in South American women to 34% in Dominican men.We performed a genome-wide association study (GWAS) of blood pressure (BP) traits in 12,278 participants from the Hispanics Community Health Study/Study of Latinos (HCHS/SOL).In the discovery phase we identified eight previously unreported BP loci.The HCHS/SOL comprises of 12,278 ethnically diverse US individuals, classified into two subgroups: Mainland (individuals with Mexican, Central American, and South American background, and a relatively large proportion of Amerindian ancestry) and Caribbean (individuals with Cuban, Dominican, and Puerto Rican background, and a relatively large proportion of African ancestry).We performed a GWAS of BP traits in the HCHS/SOL, in the Mainland and Caribbean groups separately and combined, with the goal of studying genetic diversity within Hispanics/Latinos with respect to BP traits, and to discover novel BP loci.
Hypertension prevalence varies between ethnic groups, possibly due to differences in genetic, environmental, and cultural determinants.